PUBLICATIONS

Independent

†denote equal contribution

30. Overcoming Copper Reduction Limitation in Asymmetric Substitution: Aryl-Radical-Enabled Enantioconvergent Cyanation of Alkyl Iodides

Chen, S,; Ding, D.; Yin, L.; Krause, J. A.; Liu, W.

J. Am. Chem. Soc., 2024

DOI: https://pubs.acs.org/doi/10.1021/jacs.4c11888

 
 

29. Highly Enantioselective Dearboxylative Difluoromethylation

Zhao, X.;† Wang, C.;† Yin, L.;†, Liu, W.

J. Am. Chem. Soc., 2024, 146, 43, 29297–29304

DOI: https://doi.org/10.1021/jacs.4c11257

 
 

28. Enantioconvergent Copper-Catalysed Difluoromethylation of Alkyl Halides

Ding, D.; Yin, L.; Poore, A. T.; Ho, Y.-S.; Cheng, Y-H; Hsieh, C.-T.; Yachuw, S. C.; Knieser, R. M.; Krause, J. A.; Tian, S.; Cheng, M.-J.; Liu, W.

Nat. Catal., 2024

DOI: doi.org/10.1038/s41929-024-01253-x

Preprint: https://www.researchsquare.com/article/rs-3645899/v1

 
 

27. Catalytically Relevant Organocopper(III) Complexes Formed through Aryl-Radical-Enabled Oxidative Addition

Yan, W.;† Poore, A.;† Yin, L.;† Carter, S.; Ho, Y.; Wang, C.; Yachuw, S.; Cheng, Y.; Krause, J; Cheng, M.; Zhang, S.; Tian,S.;Liu, W.

J. Am. Chem. Soc. 2024, 146, 22, 15176-15185.

DOI: doi.org/10.1021/jacs.4c01668

 
 

26. Copper–Carbon Homolysis Competes with Reductive Elimination in Well-Defined Copper(III) Complexes

Yan, W.; Carter, S.; Hsieh, C.; Krause, J.; Cheng, M.; Zhang, S.; Liu, W.

J. Am. Chem. Soc. 2023, 145, 48, 26152–26159

DOI: doi.org/10.1021/jacs.3c08510

 
 

25. Stable oganocopper(III) complexes generated via oxidative addition

Yin, L.; Liu, W.

Sci Bull. 2024;69(3) 288-289 (Invited Highlight)

24. Recent Advances in Transition-Metal-Catalyzed Sonogashira Cross-Coupling Reactions of Alkyl Electrophiles

Zhao, X.; Liu, W.

Synthesis 2023, 55, A–O (Invited Short Review)

DOI: 10.1055/s-0042-1751506

23. Aryl Radical Enabled, Copper-Catalyzed Sonogashira-Type Cross-Coupling of Alkynes with Alkyl Iodides

Zeng, X.; Wang, C.; Yan, W.; Rong, J.; Song, Y.; Xiao, Z.; Cai, A.; Liang, S. H.; Liu, W.

ACS Catal. 2023, 13 (4), 2761-2770

DOI: doi.org/10.1021/acscatal.2c05901

 
 

22. para-Hydrogen-Induced Polarization Enabled by Visible Light Activation

Chen, S.; Niu, S.; Liu, W.

ACS Cent. Sci. 2022, 8, 12, 1573–1575 (Invited Highlight)

DOI: doi.org/10.1021/acscentsci.2c01341

21. Copper-Catalyzed Difluoromethylation of Alkyl Halides Enabled by Aryl Radical Activation of Carbon–Halogen Bonds

Cai, A.†; Yan, W.†; Wang, C., Liu, W.,

Angew. Chem. Int. Ed. 2021, 60, 26896

DOI: doi/10.1002/anie.202111993

(ChemRxiv preprint: DOI: 10.33774/chemrxiv-2021-j4j5c)

 
aryl radical.jpg
 
 
 

19. Copper-Catalyzed Carbo-Difluoromethylation of Alkenes via Radical Relay

Cai, A., Yan, W., Zeng, X., Zacate, B. S., Chao, T-H., Krause, A. J., Cheng, M-J., Liu, W.

Nat. Commun. 2021, 12, 3272

DOI: 10.1038/s41467-021-23590-2

 
 

18. Copper-Catalyzed Deaminative Difluoromethylation

Zeng, X.†, Yan, W.†, Zacate, S. B., Cai, A., Wang, Y., Yang, D., Yang, K., Liu, W.

Angew. Chem. Int. Ed. 2020, 59, 16398.

DOI: 10.1002/anie.202006048

Highlights: GalChima, Org. Process Res. Dev.

 
deaminative difluoromethylation.jpg
 

17. Copper-Catalyzed, Chloroamide-Directed Benzylic C-H Difluoromethylation

Zeng, X., Yan, W.†, Paeth, M.†, Zacate, S. B.†, Hong, P-H., Wang, Y., Yang, D., Yang, K., Yan, T., Song, C., Cao, Z., Cheng, M-J., Liu, W.

J. Am. Chem. Soc. 2019, 141, 19941-19949

DOI: 10.1021/jacs.9b05363

Highlights: Synfacts, GalChimia

 
C-H difluoromethylation.jpg
 

16. Copper-Catalyzed Decarboxylative Difluoromethylation

Zeng, X., Yan, W., Zacate, S. B., Chao, T-H., Sun, X., Cao, Z., Paeth, M., Tyndall, S. B., Yang, K., Chuo, T-C., Cheng, M.-J., and Liu, W.

J. Am. Chem. Soc. 2019, 141, 11398-11403

DOI: 10.1021/jacs.9b05363

Highlights: Synfacts, Synpacts

 
Copper-CF2H.png
 

15. Csp3-Csp3 Bond-Forming Reductive Elimination from Well-Defined Copper(III) Complexes

Paeth, M., Tyndall, S. B., Chen, L-Y., Hong J-C., Carson, W. P.,  Liu, X., Sun, X. Liu, J. Yang, K., Hale, E. M., Tierney, D. L., Liu, B., Cao, Z. , Cheng M.-J., Goddard, W. A, and  Liu, W.

J. Am. Chem. Soc. 2019, 141, 3153-3159

DOI: 10.1021/jacs.8b12632

 
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14. Electrochemical benzylic oxidation of C–H bonds

Marko, J.A., Durgham. A, Bretz, S. L. , Liu, W.

Chem. Commun., 2019, 55, 937-940

DOI: 10.1039/C8CC08768G

13. Tuning Gold Nanoparticles with Chelating Ligands for Highly Efficient Electrocatalytic CO2 Reduction

Cao Z.†, Zacate, S. B.†, Sun, X.†, Liu, J. Hale, E. M.; Carson, W. P.; Tyndall, S. B.; Xu, J; Liu, X; Liu, X; Song, C.; Luo, J-h; Cheng, M-J; Wen, X. and Liu. W.

Angew. Chem. Int. Ed., 2018, 39, 12675-12679 (Hot Paper)

DOI: 10.1002/anie.201805696

12. Copper Mediated Trifluoromethylation of Benzylic Csp3‐H Bonds

Paeth, M.;† Carson, W.;†  Luo, J-H;  Tierney, L. D.; Cao, Z.; Cheng, M.-J.; Liu, W.  Chem. Eur. J., 2018, 11559-11563

DOI: 10.1002/chem.201802766

 
C-H CF3.png
 

PhD and Postdoc
11. Gong, M.;†, Cao, Z.;† Liu, W.;† Nichols E. M.,; Smith, P. S; Derrick J. S.; Liu, Yi-S; Liu J.; Wen, X,  Chang, C. J.* "Supramolecular Porphyrin Cages Assembled at Molecular–Materials Interfaces for Electrocatalytic CO Reduction", ACS Cent. Sci., 2017, 3, 1032–1040
10. Liu, W.; Huang, X.; Placzek M. S.;  Krska, S. W. McQuade, P; Hooker, J. M. Groves, J. T.*;  "Site-selective 18F fluorination of unactivated C–H bonds mediated by a manganese porphyrin",  Chem. Sci., 2018, 9, 1168-1172
9. Liu, W.; Cheng, M-J.; Nielsen, R.J.; Goddard, W. A*; Groves, J. T.*; “Probing the C–O Bond-Formation Step in Metalloporphyrin-Catalyzed C–H Oxygenation Reactions”, ACS. Catl, 2017, 7, 4182-4188
8. Liu, W.; Truillet, C.; Flavell, R. R.; Brewer T. F.; Evans, M. J; Wilson, D. W*.; Chang, C. J.* “A Reactivity Based [18F]FDG Probe for In Vivo Formaldehyde Imaging Using Positron Emission Tomography”, Chem. Sci. 2016, 7, 5503-5507
7. Liu, W.; Groves, J. T.* “Manganese Catalyzed C-H Halogenation”, Acc. Chem. Res., 2015, 48, 1727-1735
6. Huang, X.; Liu, W.; Hooker, J. M.; Groves, J. T.* “Targeted Fluorination with the Fluoride Ion by Manganese-Catalyzed Decarboxylation”, Angew. Chem. Int. Ed., 2015, 54, 5241-5245
5. Huang, X.;† Liu, W.;† Ren, H.; Neelamegam, R.; Hooker, J. M.;* Groves, J. T.*, “Late Stage Benzylic C-H Fluorination with [18F]Fluoride for PET Imaging”, J. Am. Chem. Soc., 2014, 136, 6842-6845 (†denote equal contribution)
4. Liu, W.; Huang, X; Groves, J. T.*; “Oxidative Aliphatic C-H Fluorination with Manganese Catalysts and Fluoride Ion”, Nat. Protoc., 2013, 8, 2348-2354
3. Liu, W.; Groves, J. T.*; “Manganese Catalyzed Oxidative Benzylic C-H Fluorination by Fluoride Ions”, Angew. Chem. Int. Ed., 2013, 52, 6024-6027
2. Liu, W.; Huang, X.; Cheng, M.; Nielsen, R. J.; Goddard, W. A. III; Groves, J. T.* “Oxidative Aliphatic C-H Fluorination with Fluoride Ion Catalyzed by a Manganese Porphyrin”, Science, 2012, 337, 1322–1325
1. Liu, W.; Groves, J. T.* “Manganese Porphyrin Catalyzed Selective C-H Bond Halogenations”, J. Am. Chem. Soc., 2010, 132, 12847-12849